Keto-calorie diets can reduce biological age in multiple sclerosis

The main dishes to remember:

• The calorie and keto diets have led to a reduction in metabolomic age in patients with semi relapse.
• The regimes have also led to a reduction in biomarkers indicating accelerated organic aging.

West Palm Beach, Florida – A 6 -month -old ketogenic diet and a limited 2 -month diet in calories have been associated with a significant organic age reduction in patients with sclerosis in remedial plates, according to an acts poster.

“It has been shown that biological age is accelerated in people with MS and this could be a central characteristic of the pathophysiology of the disease”, “,” Fatemeh SiavoshiMD, The postdoctoral scholarship holder of the Department of Neurology of the Johns Hopkins University School of Medicine, told Healio. “We wanted to see if we could provide a biomarker to capture accelerated aging; The first that drew our attention was imitating scheme on an empty stomach. ”

Siavoshi and his colleagues have studied if the accelerated aging linked to the MS could be slowed down or reversed thanks to fasting immersion diets, such as intermittent and ketogenic fasting diets, in a small cohort of adults with Remitting MS, at Johns Hopkins (JHU) and the University of Virginia (UVA).

In JHU, the study included 36 patients who were randomly assigned to a 1: 1: 1: 1 in three diet groups: daily calorie restrictions (22% reduction in normal daily calorie needs); Intermittent (reduction of calories 75% of normal daily needs twice a week); and stable controls (100% of normal daily needs). Participants recorded a widen score of the disability status (EDSS) scale of less than six and received a stable IV therapy diet for at least 6 months before registration or have received no previous therapy modifying the disease (DMT). Individuals also submitted a blood sample for flow cytometry at the start and the 8 week brand to determine biological age, as measured by metabolomic age.

At the UVA, the study included 39 people with an EDSS of less than six who received various DMTs and have shown no clinical relapse or a new MRI lesions activity for 6 months before registration. These individuals were invited to follow a modified Atkins diet for 6 months while limiting net carbohydrates to less than 20 g per day to increase healthy consumption of fat.

According to the results of the JHHU study, those who have the limited calorie diet demonstrated an average reduction in the metabolomic age of 6.58 years compared to patients in control groups.

In addition, data has shown that patients who had higher organic age acceleration recorded a greater reduction in T cells as well as a higher increase in CD4 native cells than patients with lower acceleration.

For the UVA study, the researchers reported that 6 -month membership of the ketogenic diet has led to an average reduction of 1.06 years per month of metabolomic age.

“We have seen a beneficial effect in people with MS,” Siavoshi told Healio. “We could see that the biological age, measured by the metabolomic age, could be reversed with a caloric restriction in a fasting diet and a ketogenic diet.”